Sony PSP 3000 Console (Vibrant Blue)

Product Information

After running the update press "X" and the custom firmware will install, all been well your PSP will now be running custom firmware until you power it off.

Note: On the 15/01/2015 Sony released PSP firmware 6.61, some three and a half years after the last 6.60 update. It's of no benefit to you updating to 6.61 after all this time, however the custom firmware has now been updated to support 6.61. So you can now follow this guide if you happen to have updated to 6.61. Pharnext announces on-schedule completion of patient enrollment in its pivotal phase III trial of PXT3003, the PREMIER trial, for the treatment of Charcot-Marie-Tooth disease type 1a. News release. Pharnext SA. May 30, 2022. Accessed July 11, 2022. https://pharnext.com/en/press-releases/pharnext-announces-on-schedule-completion-of-patient-enrollment-in-its-pivotal-phase-iii-trial-of-pxt3003-the-premier-trial-for-the-treatment-of-charcot-marie-tooth-disease-type-1a Unzip and copy the program to your PSP > Game folder like you did with the custom firmware installer, then load PSP Ident up on your PSP: Attarian S, Young P, Brannagan TH, et al. A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A. Orphanet J Rare Dis. 2021;16(1):433. doi:10.1186/s13023-021-02040-8If the firmware is permanently installed it means your PSP will boot directly in to the custom firmware when powered on, if not it means you will have to enable it again by launching a simple app. This however only needs doing from a cold boot, if you leave the PSP in standby like most people do (you probably do this without realising) then you will not need to enable it. The PSP 1000 is able to have permanent custom firmware installed via cIPL flasher. cIPL (custom IPL) installs to the nand and allows the PSP to load the custom firmware files on boot. This is the preferred method for this model over installing Infinity. Infinity itself isn’t custom firmware but an exploit that allows PRO or LME to be enabled permanently. You are free to use whatever method you prefer but this guide suggests cIPL. As for ME and PRO, you can choose whatever one you want. Both are very similar in what features they offer and you can uninstall and try the other one if you are curious. For the sake of this guide, I personally use ME and find that the plugin manager a helpful feature which isn’t included in PRO.

You will be able to play any game released to date on either 6.60 or 6.61, you will also be able to connect to the PSN and buy stuff. The best of both worlds I think you will agree

I have personally tested and made this firmware permanent on my PSP 1000 and a friends PSP 2000 (Non 88v3). If you are unsure about anything just use the PROUPDATE and enjoy custom firmware. If you ever power your PSP off fully just use the fast recovery program, there is little risk to your PSP doing this.

Dark_Alex for the initial M33 CFW who guided us mentally through several CFW generations by giving good examples on how to patch Sony OFW. The PSP 2000 is able to have permanent custom firmware installed via cIPL flasher if it’s an early revision model. Sony patched this with newer motherboard versions. cIPL (custom IPL) installs to the nand and allows the PSP to load the custom firmware files on boot. This is the preferred method for this model over installing Infinity. Infinity itself isn’t custom firmware but an exploit that allows PRO or LME to be enabled permanently. You are free to use whatever method you prefer but this guide suggests cIPL if your PSP 2000 is able to install it. As for ME and PRO, you can choose whatever one you want. Both are very similar in what features they offer and you can uninstall and try the other one if you are curious. For the sake of this guide, I personally use ME and find that the plugin manager a helpful feature which isn’t included in PRO.bbtgp and Draan for their PrxEncrypter source code to produce the signed fake vshmain module for permanent patch Remember you can only permanently install this firmware on a PSP 1000 or a PSP 2000 that is not an 88 v3 version. Now your PSP can run unsigned code we will find out if you can permanently flash the custom firmware to your PSP. CMT1A, the most common form of CMT, is caused by a duplication of the PMP22 gene that is responsible for the production of the peripheral myelin sheath protein. Its duplication leads to abnormal levels of PMP22 protein, which then leads to a failure in the production of normal myelin. In data from preclinical studies, PXT3003 was shown to suppress PMP22 production and improve neuromuscular function.